m-Chloroperbenzoic acid → Methyl 2-methylnicotinate 1-oxide

関与物質

反応手順

To a stirred solution of methyl-2-methylnicotinate (95 g, 629 mmol) in DCM (1.5 L) was added m-CPBA (119 g, 692 mmol) at 0° C. After the reaction mixture was stirred at room temperature for 16 hours, it was washed with a mixture of satd. aq. Na2SO3 and NaHCO3 solution. The organic layer was then dried over anhy. Na2SO4, filtered, and concentrated in vacuo to give a crude product (60 g, yield 57%), which was used in the next step reaction without further purification.

情報源と証拠