Acetyl chloride → HCID 86686007、化合物
反応式
F[C:2](F)(F)[C:3](O)=[O:4].[Cl:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[N:13]([C:19]1[CH:20]=[N:21][CH:22]=[C:23]([O:25][CH:26]3[CH2:30][CH2:29][NH:28][CH2:27]3)[CH:24]=1)[C:12]2([CH3:32])[CH3:31].CCN(CC)CC.C(Cl)(=O)C>O>[C:3]([N:28]1[CH2:29][CH2:30][CH:26]([O:25][C:23]2[CH:24]=[C:19]([N:13]3[C:12]([CH3:32])([CH3:31])[C:11]4[C:15](=[CH:16][CH:17]=[C:9]([Cl:8])[CH:10]=4)[C:14]3=[O:18])[CH:20]=[N:21][CH:22]=2)[CH2:27]1)(=[O:4])[CH3:2]参加物
5
実験手順
To a solution of 5-chloro-3,3-dimethyl-2-[5-(pyrrolidin-3-yloxy)-pyridin-3-yl]-2,3-dihydro-isoindol-1-one trifluoro acetic acid salt (94.2 mg, 0.2 mmol) was added Et3N (1 mmol) and acetyl chloride (23.4 mg, 0.3 mmol) at 0° C. The resulting reaction mixture was stirred at room temperature for 1 hour before it was poured into H2O (1 mL) and extracted with EtOAc (15 mL×2). The combined organic layers were washed with brine, dried over anhy. Na2SO4, filtered and concentrated in vacuo to give a crude product which was purified by PrepHPLC to give the title compound (25.5 mg, 35%) as a white solid. MS: 400.2 (M+H+).