化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butanol → N,N-diethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butanol | HCID 6386 | — |
| 反応物 | Diethylamine | HCID 8021 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 12-Chloro-7-thia-9,11-diazatricyclo(6.4.0.0,2,6)dodeca-1(12),2(6),8,10-tetraene | HCID 789817 | — |
| 溶媒 | Hydrate;hydrochloride | HCID 21885828 | — |
| 生成物 | N,N-diethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine | HCID 717848 | — |
反応手順
To a slurry of 0.044 g 4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine (0.196 mmol) in 1 mL of 100:1 H2O/HCl was added 0.014 g (0.02 mL, 0.106 mmol) diethylamine. The mixture was heated to reflux, and an additional 0.2 mL diethylamine and 1 mL of t-butanol were added and heated continued at reflux for an additional 1 h. TLC (20% EtOAc/80% pet ether) showed complete reaction and the 1H NMR of the isolated material was consistent with the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849638B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-dcfb3b429c2544d6bb6f40646bccd630 |
| 出典メモ | uspto-grants-2005_02 |