Ethanol → HCID 178440334、化合物

HRID 2278860ノート

反応式

HRID 2278860 の反応式
O=[C:2]([CH2:7][CH2:8][CH3:9])[C:3]([O:5]C)=O.[F:10][C:11]1[CH:30]=[CH:29][CH:28]=[CH:27][C:12]=1[CH2:13][N:14]1[C:18]2=[N:19][CH:20]=N[CH:22]=[C:17]2[C:16]([C:23](=[NH:26])[NH:24][NH2:25])=[N:15]1.[CH2:31](O)C>>[F:10][C:11]1[CH:30]=[CH:29][CH:28]=[CH:27][C:12]=1[CH2:13][N:14]1[C:18]2=[N:19][CH:20]=[CH:31][CH:22]=[C:17]2[C:16]([C:23]2[N:24]=[N:25][C:2]([CH2:7][CH2:8][CH3:9])=[C:3]([OH:5])[N:26]=2)=[N:15]1

参加物

4

反応物 3

HCID 702Ethanol2 回HCID 642256Methyl 2-OxovalerateHCID 178512736HCID 178512736、化合物

生成物 1

HCID 178440334HCID 178440334、化合物

実験手順

0.916 g (7.035 mmol) of methyl 2-oxopentanoate in 15 ml of ethanol were initially introduced and heated to reflux. Then, 2.000 g (7.035 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidohydrazide suspended in 20 ml of ethanol were added and the mixture was heated under reflux overnight. After cooling, the mixture was filtered off with suction, and the filtercake was washed with a little ethanol and dried under high vacuum. This gave 1.75 g of the target compound (purity 92%; 63% of theory).

後処理

  1. temperatureheated to reflux
  2. additionwere added
  3. temperaturethe mixture was heated
  4. temperatureunder reflux overnight
  5. temperatureAfter cooling
  6. filtrationthe mixture was filtered off with suction
  7. washthe filtercake was washed with a little ethanol
  8. customdried under high vacuum

出典と根拠

ORDレコード
ord-00eec5bf659c4cf48ab0c61a2325d3a0
出典データセット
uspto-grants-2015_09
特許番号
US09133191B2

反応ノート

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