Potassium Carbonate → 3,4-Dimethylbiphenyl

関与物質

役割	名称	HCID	仕込み量
反応物	Potassium Carbonate	HCID 11430	—
反応物	4-Chloro-o-xylene	HCID 32886	—
反応物	Phenylboronic Acid	HCID 66827	—
触媒	palladium(II) acetate	HCID 167845	—
触媒	Sodium 2'-(dicyclohexylphosphino)-2,6-dimethoxybiphenyl-3-sulfonate	HCID 23677046	—
溶媒	Water	HCID 962	—
生成物	3,4-Dimethylbiphenyl	HCID 20492	99%

反応手順

The general procedure described in Example 3 was used with 3,4-dimethyl-chlorobenzene (0.140 mL, 1.00 mmol), phenylboronic acid (157 mg, 1.20 mmol), Pd(OAc)2 (4.5 mg, 0.020 mmol, 2 mol %), sodium 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl-3′-sulfonate (20.0 mg, 0.040 mmol, 4 mol %), K2CO3 (276 mg, 2.00 mmol), water (1.0 mL), 10 h, room temperature. The product was isolated as a colorless oil (151 mg, 99%). 1H NMR (400 MHz, CDCl3) δ: 7.82 (d, 2H, J=7.6 Hz), 6.81-7.55 (m, 6H), 2.24 (s, 6H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07560596B2
出典データセット	uspto-grants-2009_07
ORD ID	ord-0fa6bfda377847089237a7f9d9a9b847
出典メモ	uspto-grants-2009_07