ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Hydrochloric Acid → 3-Fluoro-4-[3-methyl-4-(2-phenyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol

HRID 2279090
ノート
印刷プレビュー

反応式

HRID 2279090 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][C:22]=3[F:28])[N:18]=[C:17]3[N:29](C4CCCCO4)[N:30]=[C:31]([CH3:32])[C:16]=23)[CH:10]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[F:28][C:22]1[CH:23]=[C:24]([OH:27])[CH:25]=[CH:26][C:21]=1[C:19]1[N:18]=[C:17]2[NH:29][N:30]=[C:31]([CH3:32])[C:16]2=[C:15]([CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH:10]2[C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH:20]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 1366231874-[6-(2-fluoro-4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-3-phenyl-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 1784344133-Fluoro-4-[3-methyl-4-(2-phenyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol収率 51%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

178 mg 4-[6-(2-fluoro-4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-3-phenyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 3 ml dry 1,4-dioxane and 2 ml HCl (4N in 1,4-dioxane) was added. After stirring the reaction at r.t. for 30 min the volatiles were removed in vacuo and the resulting residue was purified by preparative HPLC (C18 column, acetonitrile/water gradient). 63 mg (51%) of the title compound were obtained.

後処理

  1. customthe reaction at r.t. for 30 min the volatiles
  2. customwere removed in vacuo
  3. customthe resulting residue was purified by preparative HPLC (C18 column, acetonitrile/water gradient)

出典と根拠

ORDレコード
ord-5f712bb02b6145ebafd89812ed0b31f4
出典データセット
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09133181B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート