Hydrochloric Acid → HCID 178434390、化合物
反応式
COC[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:16]=[C:15]3[N:17](C4CCCCO4)[N:18]=[C:19]([CH3:20])[C:14]3=[C:13]([CH2:27][N:28]3[CH2:33][CH:32]([CH3:34])[N:31]([CH2:35][C:36]4[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=4)[CH2:30][C:29]3([CH3:43])[CH3:42])[CH:12]=2)=[CH:7][CH:6]=1.Cl>O1CCOCC1>[CH3:20][C:19]1[C:14]2[C:15](=[N:16][C:11]([C:8]3[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=3)=[CH:12][C:13]=2[CH2:27][N:28]2[CH2:33][CH:32]([CH3:34])[N:31]([CH2:35][C:36]3[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=3)[CH2:30][C:29]2([CH3:43])[CH3:42])[NH:17][N:18]=1参加物
4
実験手順
65 mg of 6-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5-trimethyl-4-pyridin-3-ylmethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridine were dissolved in 1.5 ml of 1,4-dioxane and treated with 1.5 ml of hydrochloric acid (4 M in dry dioxane). After standing at rt for 10 min the volatiles were removed in vacuo. The residue purified by HPLC and 65 mg of the title compound were obtained.