Ethanol → Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate

HRID 2279203

反応式

HRID 2279203 の反応式
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][C:6](=O)[C:7](Cl)(Cl)Cl)[CH3:2].[NH2:13][NH2:14].Cl.[CH3:16][CH2:17][OH:18]>>[CH2:1]([O:3][C:4]([C:5]1[NH:13][N:14]=[C:7]([O:18][CH2:17][CH3:16])[CH:6]=1)=[O:12])[CH3:2]

参加物

4

反応物 3

HCID 702EthanolHCID 77294Ethyl 4,4,4-trichloro-3-oxobutyrateHCID 115031Hydrazinium chloride

生成物 1

HCID 68571888Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate

実験手順

4,4,4-Trichloro-3-oxo-butyric acid ethyl ester (Int 8, 1 eq) and H2NNH2.HCl (1.1 eq) are mixed in EtOH. The resulting mixture is refluxed overnight. The mixture is then evaporated and the obtained crude is purified by chromatography to give Int 9 and 5-ethoxy-2H-pyrazole-3-carboxylic acid ethyl ester (Int 10).

後処理

  1. temperatureThe resulting mixture is refluxed overnight
  2. customThe mixture is then evaporated
  3. customthe obtained crude
  4. customis purified by chromatography

出典と根拠

ORDレコード
ord-31cc93264c994d118e695060f06583d0
出典データセット
uspto-grants-2015_09
特許番号
US09133210B2

関連ノート

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