3-Hydroxybutyric Acid → (-)-3-t-Butyldimethylsilyloxybutyric acid

HRID 2279205ノート

反応式

HRID 2279205 の反応式
[OH:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[CH3:8][C:9]([Si:12](Cl)([CH3:14])[CH3:13])([CH3:11])[CH3:10]>C(Cl)Cl>[C:9]([Si:12]([CH3:14])([CH3:13])[O:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5])([CH3:11])([CH3:10])[CH3:8]

参加物

4

反応物 2

HCID 4413-Hydroxybutyric AcidHCID 28928tert-Butyldimethylsilyl chloride

生成物 1

HCID 13712781(-)-3-t-Butyldimethylsilyloxybutyric acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-Hydroxy-butyric acid (500 mg, 4.8 mmol) is dissolved in a mixture of TBSCl (1.5 g, 10.1 mmol) in dry DCM (48 mL). The resulting mixture is stirred overnight at room temperature. The resulting suspension is then filtered and the obtained residues are washed with DCM, then stirred in Et2O and filtered. The obtained filtrate is evaporated to give the desired product that is used as such.

後処理

  1. filtrationThe resulting suspension is then filtered
  2. washthe obtained residues are washed with DCM
  3. stirringstirred in Et2O
  4. filtrationfiltered
  5. customThe obtained filtrate is evaporated

出典と根拠

ORDレコード
ord-d48cd4783ab941b89a970aa392636394
出典データセット
uspto-grants-2015_09
特許番号
US09133210B2

反応ノート

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