化工社化工社 化学情報印刷レポート · 研究参考用
3-Chlorobenzoic Acid → (1,1'-Biphenyl)-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chlorobenzoic Acid | HCID 447 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Phenylboronic Acid | HCID 66827 | — |
| 反応物 | Sodium 2'-(dicyclohexylphosphino)-2,6-dimethoxybiphenyl-3-sulfonate | HCID 23677046 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 生成物 | (1,1'-Biphenyl)-3-carboxylic acid | HCID 12854 | — |
反応手順
The general procedure described in Example 3 was used with 3-chlorobenzoic acid (157 mg, 1.00 mmol), phenylboronic acid (145 mg, 1.20 mmol), Pd(OAc)2 (4.5 mg, 0.020 mmol, 2 mol %), sodium 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl-3′-sulfonate (20.0 mg, 0.040 mmol, 4 mol %), K2CO3 (345 mg, 2.50 mmol), solvent (see FIG. 5) (2.0 mL), 14 h, temperature. The conversion and yield were determined using 1H NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560596B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-fa0ba15a14634939907da955358fc750 |
| 出典メモ | uspto-grants-2009_07 |