Dichloromethane → Diethyl (4-{[4-({5-fluoro-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

反応式

Br[C:2]1[C:7]([F:8])=[CH:6][C:5]([NH:9][C:10]2[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][N:13]=[C:12]([NH:20][C:21]3[CH:35]=[CH:34][C:24]([CH2:25][P:26](=[O:33])([O:30][CH2:31][CH3:32])[O:27][CH2:28][CH3:29])=[CH:23][C:22]=3[O:36][CH3:37])[N:11]=2)=[C:4]([C:38](=[O:41])[NH:39][CH3:40])[CH:3]=1.CC1(C)C(C)(C)OB([C:50]2[CH:51]=[N:52][N:53]([CH2:55][CH2:56][CH2:57][OH:58])[CH:54]=2)O1.ClCCl.C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1.O.C1C=CC(P([C]2[CH][CH][CH][CH]2)C2C=CC=CC=2)=CC=1.C1C=CC(P([C]2[CH][CH][CH][CH]2)C2C=CC=CC=2)=CC=1.Cl[Pd]Cl.[Fe]>[F:8][C:7]1[C:2]([C:50]2[CH:51]=[N:52][N:53]([CH2:55][CH2:56][CH2:57][OH:58])[CH:54]=2)=[CH:3][C:4]([C:38](=[O:41])[NH:39][CH3:40])=[C:5]([NH:9][C:10]2[C:15]([C:16]([F:17])([F:19])[F:18])=[CH:14][N:13]=[C:12]([NH:20][C:21]3[CH:35]=[CH:34][C:24]([CH2:25][P:26](=[O:33])([O:27][CH2:28][CH3:29])[O:30][CH2:31][CH3:32])=[CH:23][C:22]=3[O:36][CH3:37])[N:11]=2)[CH:6]=1