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2,4-Dimethylaniline → (2S,4S)-4-fluoro-1-[[N-[4-[N-(2,4-dimethylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dimethylaniline | HCID 7250 | — |
| 反応物 | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| 生成物 | (2S,4S)-4-fluoro-1-[[N-[4-[N-(2,4-dimethylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile | HCID 57756740 | — |
反応手順
In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2,4-dimethylaniline (42.3 μL) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-(2,4-dimethylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (22.4 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560569B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-72e3d6f9b1e243338ac6f25522de3b6a |
| 出典メモ | uspto-grants-2009_07 |