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HRID 228023作成日：2026年10月26日

2-Chloro-p-toluidine → (2S,4S)-1-[[N-[4-[N-(2-chloro-4-methylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile

https://huagongshe.com/reaction/228023

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloro-p-toluidineHCID 12007—
反応物(2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrileHCID 57634365—
生成物(2S,4S)-1-[[N-[4-[N-(2-chloro-4-methylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrileHCID 57756843—

反応手順

In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2-chloro-4-methylaniline (41.8 μL) were used to obtain (2S,4S)-1-[[N-[4-[N-(2-chloro-4-methylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (22.6 mg).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07560569B2
出典データセットuspto-grants-2009_07
ORD IDord-7d1a8cef68a141f7aabc4e7f3420ba95
出典メモuspto-grants-2009_07