化工社化工社 化学情報印刷レポート · 研究参考用
4-(Piperidin-1-yl)aniline → (2S,4S)-4-fluoro-1-[[N-[4-[N-(4-piperidinylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Piperidin-1-yl)aniline | HCID 413501 | — |
| 反応物 | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| 生成物 | (2S,4S)-4-fluoro-1-[[N-[4-[N-(4-piperidinylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile | HCID 57756857 | 19.6% |
反応手順
In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and N-(4-aminophenyl)piperidine (61.4 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-(4-piperidinylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (14.6 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560569B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-0e990551bf114d7fa04613718aa3609e |
| 出典メモ | uspto-grants-2009_07 |