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2-(4-Aminophenyl)benzothiazole → (2S,4S)-1-[[N-[4-[N-[4-(benzothiazol-2-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(4-Aminophenyl)benzothiazole | HCID 234475 | — |
| 反応物 | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| 生成物 | (2S,4S)-1-[[N-[4-[N-[4-(benzothiazol-2-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57756769 | 12.7% |
反応手順
In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-(benzothiazol-2-yl)aniline (51.0 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-[4-(benzothiazol-2-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (10.4 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560569B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-ed64cc21e8e64848adb9b24729f6ac73 |
| 出典メモ | uspto-grants-2009_07 |