4-Heptanamine → (2S,4S)-4-fluoro-1-[[N-[4-[N-(4-heptyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile
反応式
[C:1]([C:4]12[CH2:11][CH2:10][C:7]([NH:12][CH2:13][C:14]([N:16]3[CH2:20][C@@H:19]([F:21])[CH2:18][C@H:17]3[C:22]#[N:23])=[O:15])([CH2:8][CH2:9]1)[CH2:6][CH2:5]2)([OH:3])=O.[CH3:24][CH2:25][CH2:26][CH:27]([NH2:31])[CH2:28][CH2:29][CH3:30]>>[F:21][C@@H:19]1[CH2:20][N:16]([C:14](=[O:15])[CH2:13][NH:12][C:7]23[CH2:6][CH2:5][C:4]([C:1]([NH:31][CH:27]([CH2:28][CH2:29][CH3:30])[CH2:26][CH2:25][CH3:24])=[O:3])([CH2:9][CH2:8]2)[CH2:11][CH2:10]3)[C@H:17]([C:22]#[N:23])[CH2:18]1参加物
3
実験手順
In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-heptylamine (50.9 μL) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-(4-heptyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (36.4 mg).
出典と根拠
- ORDレコード
- ord-f29fc98972ad4b99abe5beca7bfaa633