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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

Potassium Iodide → N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-2-(6-(dimethylamino)pyridazine-3-yloxy)-N-methylacetamide

HRID 2280952

印刷プレビュー

反応式

HRID 2280952 の反応式

Cl[C:2]1[N:7]=[N:6][C:5]([O:8][CH2:9][C:10]([N:12]([CH:14]2[CH2:19][CH2:18][N:17]([C:20]([CH:22]3[CH2:24][CH2:23]3)=[O:21])[CH2:16][CH2:15]2)[CH3:13])=[O:11])=[CH:4][CH:3]=1.[CH3:25][NH:26][CH3:27].O1CCCC1.[I-].[K+].C(N(CC)CC)C>C(O)CCC>[CH:22]1([C:20]([N:17]2[CH2:18][CH2:19][CH:14]([N:12]([CH3:13])[C:10](=[O:11])[CH2:9][O:8][C:5]3[N:6]=[N:7][C:2]([N:26]([CH3:27])[CH3:25])=[CH:3][CH:4]=3)[CH2:15][CH2:16]2)=[O:21])[CH2:24][CH2:23]1

参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 4875Potassium Iodide

HCID 8471Triethylamine

HCID 22320367Dimethylamine tetrahydrofuran

HCID 866419642-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamide

生成物 1

HCID 68412572N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-2-(6-(dimethylamino)pyridazine-3-yloxy)-N-methylacetamide収率 19%

試薬・触媒・溶媒

1

HCID 2631-Butanol溶媒

反応条件

温度: 110 °C

実験手順

A mixture of Compound 135 (60 mg), 2M dimethylamine/tetrahydrofuran solution (766 μL), potassium iodide (2.82 mg), triethylamine (23.7 μL) and n-butanol (11.0 mL) was stirred at 110° C. for 2 days in a sealed tube. Subsequently, the reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:3 to 99:1) to give 12.1 mg (19% yield) of the desired product as a pale yellow amorphous.

後処理

concentrationSubsequently, the reaction mixture was concentrated under reduced pressure
customthe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:3 to 99:1)

出典と根拠

ORDレコード: ord-502b5d9c7b554d8db9439efe09704054
出典データセット: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09139559B2

反応ノート

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