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Acetyl chloride → N-cylcohexyl-N-(2-furan-2-yl-6-trifluoromethylimidazo[1,2-a]pyridin-3-yl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Furfural | HCID 7362 | — |
| 反応物 | Cyclohexyl isocyanide | HCID 79129 | — |
| 反応物 | 2-Amino-5-(trifluoromethyl)pyridine | HCID 735862 | — |
| 溶媒 | Perchloric Acid | HCID 24247 | — |
| 生成物 | N-cylcohexyl-N-(2-furan-2-yl-6-trifluoromethylimidazo[1,2-a]pyridin-3-yl)-acetamide | HCID 9865235 | — |
反応手順
Compound (34) was prepared from 1.0 ml of 2-amino-5-trifluoromethylpyridine solution (0.1 M, DCM), 0.575 ml of cyclohexyl isocyanide solution (0.2 M, DCM), 0.500 ml of furfural solution (0.3 M, DCM), and 10 μl of perchloric acid (w=20%), and reaction with acetyl chloride. Excess acetyl chloride was removed under reduced pressure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849642B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-d387b66b0d28469785ad0fe97ff93600 |
| 出典メモ | uspto-grants-2005_02 |