Hydrochloric Acid → HCID 67464347、化合物

HRID 2281176ノート

反応式

HRID 2281176 の反応式
[C:1]1([C:7]2[O:8][CH:9]=[C:10]3[C:18]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[N:12](S(C4C=CC=CC=4)(=O)=O)[C:11]=23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].Cl>CS(C)=O.O>[C:1]1([C:7]2[O:8][CH:9]=[C:10]3[C:18]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[NH:12][C:11]=23)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 104070034H-Furo[3,4-b]indole, 3-phenyl-4-(phenylsulfonyl)-

生成物 1

HCID 67464347HCID 67464347、化合物

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

45 g (123 mmol) of 3-phenyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole and 48 g (856 mmol) of potassium hydroxide in 65 ml of DMSO and 21 ml of water are heated under reflux for 1 h. The mixture is subsequently cooled to room temperature, neutralised using 1M HCl solution and extracted with dichloromethane. The solvent is evaporated in vacuo, and the residue is purified by chromatography (heptane/ethyl acetate 10:1). Yield: 22.4 g (96 mmol), 80%.

後処理

  1. temperatureunder reflux for 1 h
  2. extractionextracted with dichloromethane
  3. customThe solvent is evaporated in vacuo
  4. customthe residue is purified by chromatography (heptane/ethyl acetate 10:1)

出典と根拠

ORDレコード
ord-a0631ac15b5a422ba9876dcaa1b17a25
出典データセット
uspto-grants-2015_09
特許番号
US09139582B2

反応ノート

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