Phosphorus oxychloride → 3-(Propan-2-yl)benzonitrile

HRID 2281279

反応式

HRID 2281279 の反応式
[CH:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:9])=O)([CH3:3])[CH3:2].O=P(Cl)(Cl)Cl>>[CH:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]#[N:9])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 2579543-(Propan-2-yl)benzamide

生成物 1

HCID 2584403-(Propan-2-yl)benzonitrile収率 80.4%

実験手順

A solution of the above amide (4.20 g, 25.7 mmol) in POCl3 (36.0 g, 236 mmol) was stirred at 80° C. for 18 h. The solution was concentrated and the residue was poured into water (100 mL). The mixture was exacted with EtOAc. The organic layers were combined, washed by brine, dried over Na2SO4 and concentrated to give 3-isopropyl-benzonitrile (3.00 g, 80%).

後処理

  1. concentrationThe solution was concentrated
  2. additionthe residue was poured into water (100 mL)
  3. washwashed by brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-b40b6c01aa504cb085c13f455ac6611a
出典データセット
uspto-grants-2015_09
特許番号
US09139580B2

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