Chlorosuccinimide → HCID 57990315、化合物

HRID 2281425ノート

反応式

HRID 2281425 の反応式
[Cl:1][C:2]1[N:3]=[C:4]([NH:11][CH:12]2[CH2:15][CH2:14][CH2:13]2)[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.C1C(=O)N([Cl:23])C(=O)C1>C(Cl)Cl>[Cl:1][C:2]1[N:3]=[C:4]([NH:11][CH:12]2[CH2:15][CH2:14][CH2:13]2)[C:5]2[C:10]([Cl:23])=[CH:9][NH:8][C:6]=2[N:7]=1

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 57990291HCID 57990291、化合物

生成物 1

HCID 57990315HCID 57990315、化合物収率 19.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 2-chloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (102 mg, 0.460 mmol) in CH2Cl2 (5 mL) at room temperature, NCS (68 mg, 0.51 mmol) was added. The mixture was stirred at reflux for 18 h. After being concentrated in vacuo, the residue was purified by HPLC to give 2,5-dichloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (23 mg).

後処理

  1. temperatureat reflux for 18 h
  2. concentrationAfter being concentrated in vacuo
  3. customthe residue was purified by HPLC

出典と根拠

ORDレコード
ord-cee72021a83640a6bc1bf58c01e54bdd
出典データセット
uspto-grants-2015_09
特許番号
US09139581B2

反応ノート

読み込み中…