Ammonia → 2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.[NH3:12]>CCOC(C)=O>[Cl:1][C:2]1[N:3]=[C:4]([NH2:12])[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A mixture of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (0.1 g, 0.53 mmol) in Ammonia (7 N in MeOH, 1 mL) was heated at 100° C. for 24 h, then it was diluted with EtOAc, washed with Sat. NaHCO3, brine, dried and concentrated to give 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-amine (0.06 g).
後処理
- washwashed with Sat. NaHCO3, brine
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-03501a093aa144c79d5062695e34fdd9
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09139581B2
反応ノート
読み込み中…