tert-Butyl piperazine-1-carboxylate → 1-(4-(4-(5-Fluoro-4-(piperazin-1-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone
反応式
NCC1C[CH2:7][N:6]([C:9]2[C:14]([F:15])=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][N:26]([C:29](=[O:31])[CH3:30])[CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:10]=2)[CH2:5][CH2:4]1.[C:32]([N:39]1CCNCC1)(OC(C)(C)C)=O>>[F:15][C:14]1[C:9]([N:6]2[CH2:5][CH2:4][NH:39][CH2:32][CH2:7]2)=[N:10][C:11]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:24][CH2:25][N:26]([C:29](=[O:31])[CH3:30])[CH2:27][CH2:28]3)=[CH:19][CH:18]=2)=[N:12][CH:13]=1参加物
3
実験手順
The titled compound was synthesized analogously as compound 1-(4-(4-(4-(4-(aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone, by using 1-Boc-piperazine. MS 400.3 (M+H); UV 203.8, 268.8 nm.
出典と根拠
- ORDレコード
- ord-4d2085897604433ca6a2c63779236dd4
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09139581B2
反応ノート
読み込み中…