Ammonia → ((S)-4-Amino-4-carbamoyl-butyl)-carbamic acid benzyl ester
反応式
CO[C:3](=[O:20])[C@@H:4]([NH2:19])[CH2:5][CH2:6][CH2:7][NH:8][C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10].[NH3:21]>CO>[CH2:12]([O:11][C:9](=[O:10])[NH:8][CH2:7][CH2:6][CH2:5][C@H:4]([NH2:19])[C:3](=[O:20])[NH2:21])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1参加物
4
実験手順
(S)-2-Amino-5-benzyloxycarbonylamino-pentanoic acid methyl ester (2.80 g, 9.99 mmol) and 7M NH3 in MeOH (20 ml) is stirred at room temperature for 72 hours. The reaction mixture is evaporated to dryness in vacuo to yield a white solid. The white solid is suspended in diethyl ether before filtration and drying to yield ((S)-4-Amino-4-carbamoyl-butyl)-carbamic acid benzyl ester.
後処理
- customThe reaction mixture is evaporated to dryness in vacuo
- customto yield a white solid
- filtrationThe white solid is suspended in diethyl ether before filtration
- customdrying
出典と根拠
- ORDレコード
- ord-a215e9237a8b400abd4c8ae6f311502e
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09139586B2
反応ノート
読み込み中…