Water → 7-chloro-1H-indazole-5-carboxylic acid
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]#N)[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2.[OH2:13].[OH-:14].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]([OH:14])=[O:13])[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2参加物
5
実験手順
To a mixture of 7-chloro-1H-indazole-5-carbonitrile (1.36 g, 7.66 mmol) in ethanol (52.5 mL) was added water (17.5 mL) and potassium hydroxide (6.44 g, 115 mmol). The reaction mixture was heated at reflux for 16 hours. The reaction mixture was cooled to room temperature, extracted twice with ethyl ether, acidified the aqueous with 1N hydrochloric acid and the resultant precipitate was filtered to afford 7-chloro-1H-indazole-5-carboxylic acid as a brown solid (900 mg, 60%): −ESI MS (M−H) 195.2.
後処理
- temperatureThe reaction mixture was heated
- temperatureat reflux for 16 hours
- extractionextracted twice with ethyl ether
- filtrationthe resultant precipitate was filtered
出典と根拠
- ORDレコード
- ord-5958b345366849e4927e8d5370d7c007
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09139587B2
反応ノート
読み込み中…