Sulfuric Acid → 3-[Ethyl(hydroxy)phosphoryl]propanoic acid
反応式
[Na+].[CH2:2]([P:4]([OH:11])([CH2:6][CH2:7][C:8]([O-:10])=[O:9])=[O:5])[CH3:3].S(=O)(=O)(O)O>>[CH2:2]([P:4]([OH:11])([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[O:5])[CH3:3]参加物
3
実験手順
In the aqueous solution of 420 g (2 mol) of 3-(ethylhydroxyphosphinyl)propionic acid sodium salt (produced as in Example 12) is rendered acidic with about 196 g of concentrated sulfuric acid and the water is distilled off in vacuo. The residue was taken up in tetrahydrofuran and extracted. The insoluble salts were filtered off. The solvent of the filtrate was removed in vacuo and the residue was recrystallized from acetone to obtain 325 g (98% of theory) of 3-(ethylhydroxyphosphinyl)-propionic acid as colorless solid.
後処理
- distillationthe water is distilled off in vacuo
- extractionextracted
- filtrationThe insoluble salts were filtered off
- customThe solvent of the filtrate was removed in vacuo
- customthe residue was recrystallized from acetone
出典と根拠
- ORDレコード
- ord-1e84d5a3e98a470ca21dece40bd98be2
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09139714B2
反応ノート
読み込み中…