(E)-2-(3,4-dichlorophenyl)ethenesulfonyl chloride → (E)-2-(2-(3,4-Dichlorophenyl)vinylsulfonamido)-4,6-difluorobenzenesulfonamide
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[CH:16]=[C:17](/[CH:22]=[CH:23]/[S:24](Cl)(=[O:26])=[O:25])[CH:18]=[CH:19][C:20]=1[Cl:21]>>[Cl:14][C:15]1[CH:16]=[C:17](/[CH:22]=[CH:23]/[S:24]([NH:1][C:2]2[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=2[S:10]([NH2:13])(=[O:12])=[O:11])(=[O:26])=[O:25])[CH:18]=[CH:19][C:20]=1[Cl:21]参加物
3
実験手順
The title compound was synthesized as described for Example 194 a) in 49% yield, starting from 2-amino-4,6-difluorobenzenesulfonamide and (E)-2-(3,4-dichlorophenyl)ethenesulfonyl chloride (1.5 equiv.). Purification by column chromatography, using chloroform/methanol (95:5) as the eluent.
後処理
- customPurification by column chromatography