2-Amino-5-cyanobenzene-1-sulfonamide → (E)-5-Cyano-2-(2-(3,4-dichlorophenyl)vinylsulfonamido)benzenesulfonamide
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[CH:16]=[C:17](/[CH:22]=[CH:23]/[S:24](Cl)(=[O:26])=[O:25])[CH:18]=[CH:19][C:20]=1[Cl:21]>>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:1][S:24](/[CH:23]=[CH:22]/[C:17]2[CH:18]=[CH:19][C:20]([Cl:21])=[C:15]([Cl:14])[CH:16]=2)(=[O:26])=[O:25])=[C:3]([S:10]([NH2:13])(=[O:11])=[O:12])[CH:4]=1)#[N:9]参加物
3
実験手順
The title compound was synthesized as described for Example 194 a), starting from 2-amino-5-cyanobenzenesulfonamide and (E)-2-(3,4-dichlorophenyl)ethenesulfonyl chloride (1.5 equiv.). Purification by column chromatography, using chloroform/methanol (95:5-9:1) as the eluent.
後処理
- customPurification by column chromatography
出典と根拠
- ORDレコード