3,3-Dimethyl-1-butyne → HCID 57750930、化合物

HRID 2283364ノート

反応式

HRID 2283364 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:18]=[CH:17][S:16][C:15]=2[S:19]([NH2:22])(=[O:21])=[O:20])(=[O:12])=[O:11])=[CH:4][CH:3]=1.[CH3:23][C:24]([CH3:28])([CH3:27])[C:25]#[CH:26]>>[CH3:23][C:24]([CH3:28])([CH3:27])[C:25]#[C:26][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:18]=[CH:17][S:16][C:15]=2[S:19]([NH2:22])(=[O:21])=[O:20])(=[O:12])=[O:11])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 135123,3-Dimethyl-1-butyneHCID 57750944HCID 57750944、化合物

生成物 1

HCID 57750930HCID 57750930、化合物収率 18%

実験手順

The title compound was synthesized as described for Example 210 in 18% yield, starting from 3-[2-(4-bromo-phenyl)-ethanesulfonylamino]-thiophene-2-sulfonic acid amide and 3,3-dimethyl-1-butyne. Purification by column chromatography, using 50% ethyl acetate in hexanes as the eluent, followed by purification by preparative HPLC.

後処理

  1. customPurification by column chromatography
  2. customfollowed by purification by preparative HPLC

出典と根拠

ORDレコード
ord-78ee4dfebcb048c18efe9b00a43af496
出典データセット
uspto-grants-2015_09
特許番号
US09145380B2

反応ノート

読み込み中…