Boron tribromide → 2-Hydroxy-5-(trifluoromethoxy)phenylboronic acid

HRID 2283639ノート

反応式

HRID 2283639 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]([F:13])([F:12])[F:11])=[CH:5][C:4]=1[B:14]([OH:16])[OH:15].B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]([F:13])([F:11])[F:12])=[CH:5][C:4]=1[B:14]([OH:16])[OH:15]

参加物

4

反応物 2

HCID 25134Boron tribromide2 回HCID 222491602-Methoxy-5-(trifluoromethoxy)phenylboronic acid

生成物 1

HCID 666556152-Hydroxy-5-(trifluoromethoxy)phenylboronic acid収率 96.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

A suspension of 2-methoxy-5-(trifluoromethoxy)phenylboronic acid (23.0 g, 97.5 mmol) in dichloromethane (140 mL) was cooled to 0° C. and boron tribromide (9.4 mL, 10 mmol) was added drop-wise over 30 min. After stirring for 3 hours, additional boron tribromide (2 mL) was added. The reaction mixture was poured into ice water and stirred for 20 min. The dichloromethane was removed in vacuo and the white solid collected by filtration and washed with water before drying in vacuo to afford the title compound (20.8 g).

後処理

  1. stirringstirred for 20 min
  2. customThe dichloromethane was removed in vacuo
  3. filtrationthe white solid collected by filtration
  4. washwashed with water
  5. custombefore drying in vacuo

出典と根拠

ORDレコード
ord-595b9cc25da649e1960bdf82ccb64975
出典データセット
uspto-grants-2015_09
特許番号
US09145407B2

反応ノート

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