Acetone → 1H-Indole, 2-methyl-4-nitro-

HRID 2283680ノート

反応式

HRID 2283680 の反応式
[CH3:1][C:2]([CH3:4])=O.C(O[K])(C)(C)C.[N+:11]([C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17])([O-:13])=[O:12]>CS(C)=O.C(OCC)(=O)C>[CH3:1][C:2]1[NH:17][C:16]2[C:15]([CH:4]=1)=[C:14]([N+:11]([O-:13])=[O:12])[CH:20]=[CH:19][CH:18]=2

参加物

6

反応物 3

HCID 180AcetoneHCID 74233-NitroanilineHCID 178418922HCID 178418922、化合物

生成物 1

HCID 110951501H-Indole, 2-methyl-4-nitro-

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Acetone (1.0 mL) and tert-butoxy potassium (2.7 g) were added to a solution of 3-nitroaniline (1.38 g) in dimethylsulfoxide (20 ml), and the reaction solution was stirred at room temperature for 3 hours. The reaction solution was diluted with ethyl acetate, and washed successively with an aqueous ammonium chloride solution and a saturated saline solution. After drying over anhydrous sodium sulfate, the solvent was evaporated under vacuum. The residue was purified by column chromatography on silica gel (developing solvent:hexane-ethyl acetate) to obtain 2-methyl-4-nitro-1H-indole.

後処理

  1. washwashed successively with an aqueous ammonium chloride solution
  2. dry with materialAfter drying over anhydrous sodium sulfate
  3. customthe solvent was evaporated under vacuum
  4. customThe residue was purified by column chromatography on silica gel (developing solvent:hexane-ethyl acetate)

出典と根拠

ORDレコード
ord-e2ecb262ccc14118a3c587db2b791875
出典データセット
uspto-grants-2015_09
特許番号
US09145414B2

反応ノート

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