HCID 89442607、化合物 → 4-amino-6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidine-5-carbonitrile

反応式

[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]3[N:17]([CH2:30][CH2:31][N:32]4[CH2:35][CH2:34][CH2:33]4)[CH:18]=[C:19]([C:21]4[CH:26]=[CH:25][C:24]([F:27])=[C:23](OC)[CH:22]=4)[N:20]=3)[CH2:12][CH2:11]2)[N:5]=[CH:4][N:3]=1.N1(CCN2C=C(C3C=CC(F)=C(C)C=3)N=C2C2CCNCC2)CC[CH2:37]1.Cl.N1(CCN2C=C(C3C=CC(F)=C(OC)C=3)N=C2C2CCNCC2)CCC1>>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]3[N:17]([CH2:30][CH2:31][N:32]4[CH2:35][CH2:34][CH2:33]4)[CH:18]=[C:19]([C:21]4[CH:26]=[CH:25][C:24]([F:27])=[C:23]([CH3:37])[CH:22]=4)[N:20]=3)[CH2:12][CH2:11]2)[N:5]=[CH:4][N:3]=1

参加物

反応物 3

HCID 89442607HCID 89442607、化合物

HCID 89442650HCID 89442650、化合物

HCID 89442707HCID 89442707、化合物

生成物 1

HCID 894427544-amino-6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidine-5-carbonitrile

実験手順

The title compound was prepared in an analogous manner as 4-amino-6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidine-5-carbonitrile of using 4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidine instead 4-[1-(2-Azetidin-1-yl-ethyl)-4-(4-fluoro-3-methoxy-phenyl)-1H-imidazol-2-yl]-piperidine hydrochloride.

出典と根拠

ORDレコード: ord-187c1c37ce214145891a5d626b69c212
出典データセット: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09145392B2

反応ノート

読み込み中…