Urea → 7-Bromo-6-fluoroquinazoline-2,4(1H,3H)-dione
反応式
[NH2:1][C:2]1[CH:10]=[C:9]([Br:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](O)=[O:5].[NH2:13][C:14](N)=[O:15]>O>[Br:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:13][C:14](=[O:15])[NH:1]2)=[CH:7][C:8]=1[F:12]参加物
4
反応条件
- 温度
- 200 °C
実験手順
To a 100 mL round bottom flask, 2-amino-4-bromo-5-fluoro-benzoic acid (0.7 g, 2.99 mmol) and urea (1.07 g, 17.94 mmol) were added. The reaction mixture was stirred at 200° C. for 2 hours. The reaction mixture was allowed to cool to 100° C. and water was added. The aqueous reaction mixture was refluxed for 5-10 minutes and cooled to room temperature to provide the precipitate. The solid was filtered and dried to afford the title compound (400 mg, 51%). This material was taken to the next step without further purification.
後処理
- temperatureto cool to 100° C.
- temperatureThe aqueous reaction mixture was refluxed for 5-10 minutes
- temperaturecooled to room temperature
- customto provide the precipitate
- filtrationThe solid was filtered
- customdried
出典と根拠
- ORDレコード
- ord-208e306eb79944ebaf56cae83b09bdbb
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09145411B2
反応ノート
読み込み中…