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Pyridine → 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinamide | HCID 86661728 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile | HCID 86661729 | — |
反応手順
To a solution of 6-chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinamide (298 mg, 1 mmol) in acetonitrile (20 mL) was added POCl3 (460 mg, 3 mmol) and pyridine (474 mg, 6 mmol). After stirred at r.t for 2 hrs, the mixture was poured into aq. NaHCO3, extracted with EtOAc. The separated organics was dried and concentrated in vacuo to afford 6-chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile. (300 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09145429B2 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-56f71123d6f04dca91f2ce32a39b6313 |
| 出典メモ | uspto-grants-2015_09 |