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HRID 2284514作成日：2026年10月26日

Isopropylethanediol → 6-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)-2-(2-isopropoxyethoxy)-4-(trifluoromethyl)nicotinonitrile

https://huagongshe.com/reaction/2284514

反応式

関与物質

役割名称HCID仕込み量
反応物IsopropylethanediolHCID 7996—
反応物2,6-Dichloro-4-(trifluoromethyl)nicotinamideHCID 2736874—
反応物1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-olHCID 57968699—
生成物6-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)-2-(2-isopropoxyethoxy)-4-(trifluoromethyl)nicotinonitrileHCID 66726627—

反応手順

This compound was prepared from 2,6-dichloro-4-(trifluoromethyl)nicotinamide (obtained from Peakdale), 2-isopropoxyethanol, and benzo[c][1,2]oxaborole-1,5(3H)-diol in a similar manner to that of D230. 1H-NMR (400 MHz, DMSO-d6) δ (ppm) 1.72-1.75 (m, 2H), 2.05 (s, 3H), 2.38 (t, J=5.4 Hz, 2H), 4.03 (t, J=5.4 Hz, 2H), 5.03 (s, 2H), 7.13 (d, J=7.8 Hz, 1H), 7.2 (s, 1H), 8.61 (s, 1H), 9.36 (s, 1H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09145429B2
出典データセットuspto-grants-2015_09
ORD IDord-0743e16ec2f24e78826963f14a3494a2
出典メモuspto-grants-2015_09