化工社化工社 化学情報印刷レポート · 研究参考用
5-Hydroxy-2-pentanone → 6-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)-2-(4-oxopentyloxy)-4-(trifluoromethyl)nicotinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Hydroxy-2-pentanone | HCID 14066 | — |
| 反応物 | 2,6-Dichloro-4-(trifluoromethyl)nicotinamide | HCID 2736874 | — |
| 反応物 | 1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-ol | HCID 57968699 | — |
| 生成物 | 6-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)-2-(4-oxopentyloxy)-4-(trifluoromethyl)nicotinonitrile | HCID 66726636 | — |
反応手順
This compound was prepared from 2,6-dichloro-4-(trifluoromethyl)nicotinamide, 5-hydroxypentan-2-one, and benzo[c][1,2]oxaborole-1,5(3H)-diol in a similar manner to that of D230. 1H-NMR (400 MHz, DMSO-d6) δ (ppm) 1.85-1.88 (m, 2H), 1.93 (s, 3H), 2.95-2.99 (t, J=4.9 Hz, 2H), 3.91-3.94 (t, J=5.4 Hz, 2H), 5.01 (s, 2H), 7.21 (dd, J=6.0, 1.5 Hz, 1H), 7.3 (s, 1H), 7.64 (s, 1H), 7.81 (d, J=6.0 Hz, 1H), 9.26 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09145429B2 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-2cb8f676249f444cbb9819f63f821c73 |
| 出典メモ | uspto-grants-2015_09 |