Ammonia → 6-Bromopyrido[2,3-d]pyrimidin-4-amine
反応式
[Br:1][C:2]1[CH:12]=[N:11][C:5]2[N:6]=[CH:7][N:8]=[C:9](Cl)[C:4]=2[CH:3]=1.[NH3:13]>CC(O)C>[Br:1][C:2]1[CH:12]=[N:11][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH2:13])[C:4]=2[CH:3]=1参加物
4
実験手順
6-Bromo-4-chloropyrido[2,3-d]pyrimidine (1.0 g) and 4% NH3 in i-PrOH (25 mL) were stirred in a sealed tube at room temperature overnight. The pale brown heterogeneous slurry was concentrated, diluted with water and filtered. The brown solid thus collected was suction dried to obtain 6-bromopyrido[2,3-d]pyrimidin-4-amine (1.3 g, purity: 97%). 1H NMR (300 MHz, DMSO-d6) δ 9.09 (d, J=2.5 Hz, 1H), 9.01 (d, J=2.5 Hz, 1H), 8.52 (s, 1H), 8.31 (br s, 2H).
後処理
- concentrationThe pale brown heterogeneous slurry was concentrated
- additiondiluted with water
- filtrationfiltered
- customThe brown solid thus collected
- customdried
出典と根拠
- ORDレコード
- ord-0308c7787c684ed0912bb0b4200d150f
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09145433B2
反応ノート
読み込み中…