Hydrochloric Acid → (E)-4-morpholinobut-2-enoic acid
反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7]/[CH:8]=[CH:9]/[C:10]([O:12]C(C)(C)C)=[O:11])[CH2:3][CH2:2]1.Cl>C1(C)C=CC=CC=1>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7]/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11])[CH2:5][CH2:6]1参加物
4
実験手順
To (E)-tert-butyl 4-morpholino-2-butenoate (B14, 179 mg), 1.0 mol/L aqueous hydrochloric acid (4 mL) was added at room temperature, and the mixture was stirred for 1 hour and 40 minutes under reflux by heating. The reaction mixture was cooled to room temperature, and then toluene was added to the mixture, and the solvent was evaporated under reduced pressure. To the obtained residue, ethyl acetate was added. The solid matter was taken by filtration, washed with chloroform, and then dried under reduced pressure to obtain (E)-4-morpholino-2-butenoic acid (B15) hydrochloride (134 mg).
後処理
- temperatureunder reflux
- temperatureby heating
- customthe solvent was evaporated under reduced pressure
- additionTo the obtained residue, ethyl acetate was added
- filtrationThe solid matter was taken by filtration
- washwashed with chloroform
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-67bf9a846e2f486db25dedb5394d1ee6
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09145415B2
反応ノート
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