tert-butyl N-{[(3-aminophenyl)carbamoyl]methyl}carbamate → Tert-butyl (2-((3-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)phenyl)amino)-2-oxoethyl)carbamate
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:19])[CH2:10][NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH:5]=[CH:6][CH:7]=1.[C:20]([C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]2[N:34]=[C:33]([NH:35][CH2:36][CH2:37][CH3:38])[C:32]([C:39](O)=[O:40])=[CH:31][N:30]=2)=[CH:24][CH:23]=1)#[N:21]>>[C:20]([C:22]1[CH:23]=[CH:24][C:25]([NH:28][C:29]2[N:34]=[C:33]([NH:35][CH2:36][CH2:37][CH3:38])[C:32]([C:39]([NH:1][C:2]3[CH:3]=[C:4]([NH:8][C:9](=[O:19])[CH2:10][NH:11][C:12](=[O:18])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH:5]=[CH:6][CH:7]=3)=[O:40])=[CH:31][N:30]=2)=[CH:26][CH:27]=1)#[N:21]参加物
3
実験手順
By using tert-butyl (2-((3-aminophenyl)amino)-2-oxoethyl)carbamate (B1) and 2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidine-5-carboxylic acid (C5), tert-butyl (2-((3-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)phenyl)amino)-2-oxoethyl)carbamate (D8) was obtained in the same manner as that of Example 12, (1).