2,6-Pyridinedimethanamine → HCID 70545036、化合物

HRID 2285711ノート

反応式

HRID 2285711 の反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]C1C=C(Cl)C(Cl)=CC=1Cl)=O.[NH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH2:29])[N:23]=1>CN(C)C=O>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([NH:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH:29][C:8](=[O:10])[CH2:7][N:3]2[CH2:4][CH2:5][CH2:6][C:2]2=[O:1])[N:23]=1)=[O:10]

参加物

4

反応物 2

HCID 137237542,6-PyridinedimethanamineHCID 20544060HCID 20544060、化合物

生成物 1

HCID 70545036HCID 70545036、化合物収率 57%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

反応条件

温度
60 °C

実験手順

0.02 mol of 2,4,5-trichlorophenyl 2-oxo-pyrrolidineacetate is dissolved in 50 ml of dimethylformamide and reacted with a solution of 0.01 mol of 2,6-diaminomethylpyridine in 20 ml of dimethylformamide, at -5° C., whilst stirring and with the exclusion of moisture. After leaving the reaction solution to stand at room temperature for three hours, it is warmed to 60° C. for 2 hours, the solvent is then evaporated off, ether is added to the residue and the crystals which precipitate are filtered off. Melting point: 149° C., yield 57% of theory

後処理

  1. customAfter leaving the reaction solution
  2. customthe solvent is then evaporated off
  3. additionether is added to the residue
  4. filtrationthe crystals which precipitate are filtered off

出典と根拠

ORDレコード
ord-50e5dd8310a0402e81334b983cd7ea69
出典データセット
uspto-grants-1982_04
特許番号
US04324787

反応ノート

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