2,4,5-Trichlorophenol → HCID 20544060、化合物
反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([OH:10])=[O:9].[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[C:15]([Cl:19])=[CH:14][C:13]=1O.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10][C:13]1[CH:14]=[C:15]([Cl:19])[C:16]([Cl:18])=[CH:17][C:12]=1[Cl:11])=[O:9]参加物
5
反応条件
- 温度
- 20 °C
実験手順
84.8 g of 2-oxo-1-pyrrolidineacetic acid and 128.5 g of 2,4,5-trichlorophenol are dissolved in 1,500 ml of methylene chloride, 138.75 g of dicyclohexylcarbodiimide are slowly added at 0° C. and the mixture is stirred at 20° C. for three hours. The urea which has precipitated is then filtered off, the solvent is evaporated off and the residue is recrystallised from ethyl acetate.