Water → (4-Hydroxyphenyl)(3-methylphenyl)methanone

(4-Methoxyphenyl)(3-methylphenyl)methanone (603 mg) was dissolved in dichloromethane (3 ml) to prepare a solution. A boron tribromide-dichloromethane solution (1.0 M) (11 ml) was added to the solution, and the mixture was stirred at room temperature for 2 days. The reaction solution was poured into ice-cooled water, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, was dried over sodium sulfate, and was then concentrated. The residue was subjected to separation and purification by column chromatography on silica gel using hexane/ethyl acetate as a solvent to give (4-hydroxyphenyl)(3-methylphenyl)methanone (1.50 g, yield 56%).

1. customto prepare a solution
2. additionThe reaction solution was poured into ice-
3. extractionthe mixture was extracted with chloroform
4. washThe organic layer was washed with saturated brine
5. dry with materialwas dried over sodium sulfate
6. concentrationwas then concentrated
7. customThe residue was subjected to separation and purification by column chromatography on silica gel

ORDレコード

ord-32e8ef05d2084566b2a7db68dcf6d5f0

出典データセット

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07560558B2