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Triethylamine → N-(3'-Methylethylaminopropyl)-aspartic acid-4-cyclohexyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Cyclohexyl (2Z)-2-butenedioate | HCID 6913007 | — |
| 反応物 | N-Ethyl-N-methylpropane-1,3-diamine | HCID 15667718 | — |
| 生成物 | N-(3'-Methylethylaminopropyl)-aspartic acid-4-cyclohexyl ester | HCID 86738346 | — |
反応手順
43.6 g (0.2 mol+10% excess) of maleic acid-monocyclohexyl ester, 40 ml of triethylamine and 23.2 g (0.2 mol) of 3-(methylethylamino)-propylamine are reacted in the manner described in Example 1 and analogously further processed. The yield is 36.3 g (57.7% of theory) of a crystalline aspartic acid derivative which, after recrystallisation in acetone, melts at 123.5°-127.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04326069 |
| 出典データセット | uspto-grants-1982_04 |
| ORD ID | ord-9f860a1c72814bb7a7a57029e8640b03 |
| 出典メモ | uspto-grants-1982_04 |