5-(Hydroxymethyl)pyrrolidin-2-one → 6-Oxo-piperidine-2-carbaldehyde
反応式
[OH:1][CH2:2][CH:3]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1.OCC1NC(=O)CC1>>[CH:2]([CH:3]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1)=[O:1]参加物
3
実験手順
When in the procedure of Example 6 (A) an appropriate amount of 6-hydroxymethyl-2-piperidone is substituted for 5-hydroxymethyl-2-pyrrolidone, 6-formyl-2-piperidone is obtained. When an appropriate amount of 6-formyl-2-piperidone is substituted for 5-formyl-2-pyrrolidone in the procedure of Example 6 (B), 6-difluoromethyl-2-piperidone is obtained which, when substituted for 5-difluoromethyl-2-pyrrolidone in an appropriate amount in the procedure of Example 5, yields 5-amino-5-difluoromethylpentanoic acid.
出典と根拠
- ORDレコード
- ord-fd32177042dd40cb93dfc3c6295309c8
- 出典データセット
- uspto-grants-1982_04
- 特許番号
- US04326071
反応ノート
読み込み中…