(Pyrazin-2-yl)acetonitrile → HCID 136359207、化合物

HRID 2286259ノート

反応式

HRID 2286259 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][C:8]#[N:9].[N:10]([O-])=[O:11].[Na+]>C(O)(=O)C>[OH:11][N:10]=[C:7]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)[C:8]#[N:9]

参加物

4

反応物 2

HCID 12782906(Pyrazin-2-yl)acetonitrileHCID 23668193Sodium Nitrite

生成物 1

HCID 136359207HCID 136359207、化合物収率 88%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Pyrazineacetonitrile (32 g), prepared as described in British Patent Specification No. 1 021 397, was dissolved in glacial acetic acid (250 ml). The solution was stirred and 1.2 equivalents of sodium nitrite (22.3 g) were added in small portions, while the temperature was kept under 20° C. After the addition, the reaction mixture was stirred at room temperature for another two hours. The title compound separated partly from the reaction mixture. On evaporation of the solvent under reduced pressure, a solid was obtained which on recrystallization from hot water yielded α-hydroxyiminopyrazineacetonitrile (35 g, 88%). Melting point >192° C. (dec.).

後処理

  1. customwas kept under 20° C
  2. additionAfter the addition
  3. stirringthe reaction mixture was stirred at room temperature for another two hours
  4. customThe title compound separated partly from the reaction mixture
  5. customOn evaporation of the solvent under reduced pressure
  6. customa solid was obtained which
  7. customon recrystallization from hot water

出典と根拠

ORDレコード
ord-ba42fb78d84b4530927d9718759347b2
出典データセット
uspto-grants-1982_04
特許番号
US04327213

反応ノート

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