化工社化工社 化学情報印刷レポート · 研究参考用
Dicyclohexylcarbodiimide → 1-(N-Methoxyacetylglycyl)-2-cyanoaziridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | Aziridine-2-carbonitrile | HCID 118115 | — |
| 反応物 | N-(Methoxyacetyl)glycine | HCID 16775934 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(N-Methoxyacetylglycyl)-2-cyanoaziridine | HCID 23461589 | — |
反応手順
2.94 g. N-Methoxyacetylglycine are dissolved in 29 ml. tetrahydrofuran and mixed, with stirring and ice cooling, with 1.36 g. 2-cyanoaziridine and 4.3 g. dicyclohexylcarbodiimide, whereafter the reaction mixture is stirred for 2 hours. After filtering off the dicyclohexylurea, from the filtrate there are obtained 2.8 g. of crystals which, for purification, are dissolved in ethyl acetate and reprecipitated with ligroin. There is thus obtained 1-(N-methoxyacetylglycyl)-2-cyanoaziridine; M.p. 70°-72° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04267174 |
| 出典データセット | uspto-grants-1981_05 |
| ORD ID | ord-67e7568198d34822ac72e76ba96baac0 |
| 出典メモ | uspto-grants-1981_05 |