Dicyclohexylcarbodiimide → 1-(4-Ethoxycarbonylbenzoyl)-2-cyanoaziridine

HRID 2286575

反応式

HRID 2286575 の反応式
C1(N=C=NC2CCCCC2)CCCCC1.[CH2:16]([O:18][C:19]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=O)=[CH:23][CH:22]=1)=[O:20])[CH3:17].[C:30]([CH:32]1[CH2:34][NH:33]1)#[N:31]>C(OCC)C>[CH2:16]([O:18][C:19]([C:21]1[CH:22]=[CH:23][C:24]([C:25]([N:33]2[CH2:34][CH:32]2[C:30]#[N:31])=[O:27])=[CH:28][CH:29]=1)=[O:20])[CH3:17]

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 118115Aziridine-2-carbonitrileHCID 164720Monoethyl terephthalate

生成物 1

HCID 234614811-(4-Ethoxycarbonylbenzoyl)-2-cyanoaziridine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

The same compound is obtained when a solution of 1.1 g. dicyclohexylcarbodiimide in 5 ml. diethyl ether is added at 0° C. to a mixture of 0.97 g. p-ethoxycarbonylbenzoic acid and 0.34 g. 2-cyanoaziridine in 15 ml. diethyl ether, stirred for 2 hours at this temperature and then for 1 hour at ambient temperature, the precipitated dicyclohexylurea is filtered off with suction (1.13 g.), the filtrate evaporated and the evaporation residue is triturated with about 3 ml. diethyl ether. The yield is 0.66 g.; m.p. 92°-94° C.

後処理

  1. customThe same compound is obtained when a solution of 1.1 g
  2. filtrationthe precipitated dicyclohexylurea is filtered off with suction (1.13 g.)
  3. customthe filtrate evaporated
  4. customthe evaporation residue is triturated with about 3 ml

出典と根拠

ORDレコード
ord-c576984d0ea24dad9a368446f6412026
出典データセット
uspto-grants-1981_05
特許番号
US04267174

関連ノート

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