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Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)- → alpha-Cyano-m-phenoxybenzyl 4-(3-fluorophenyl)-2-isopropyl-3-butenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)- | HCID 93218 | — |
| 反応物 | (3-Fluorophenyl)acetaldehyde | HCID 15811999 | — |
| 反応物 | 4-(3-Fluorophenyl)-2-isopropyl-3-butenoic acid | HCID 53669376 | — |
| 反応物 | Ethyl 4-(3-fluorophenyl)-2-isopropyl-3-butenoate | HCID 54533755 | — |
| 反応物 | KOH MeOH Water | HCID 86591755 | — |
| 生成物 | alpha-Cyano-m-phenoxybenzyl 4-(3-fluorophenyl)-2-isopropyl-3-butenoate | HCID 53932607 | — |
反応手順
3-Fluorophenylacetaldehyde is converted into ethyl 4-(3-fluorophenyl)-2-isopropyl-3-butenoate using the reaction of Example 9. The ester is hydrolyzed using KOH/MeOH/H2O to 4-(3-fluorophenyl)-2-isopropyl-3-butenoic acid, which is converted to the acid chloride and reacted with α-cyano-m-phenoxybenzyl alcohol to yield α-cyano-m-phenoxybenzyl 4-(3-fluorophenyl)-2-isopropyl-3-butenoate, MS m/e 429 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04267359 |
| 出典データセット | uspto-grants-1981_05 |
| ORD ID | ord-f7f970fae2fa4bbf93036adf29981be6 |
| 出典メモ | uspto-grants-1981_05 |