Hydrochloric Acid → 3-[5-tert-Butyl-3-isoxazolyl]-4-hydroxy-1-methyl-2-imidazolidinone

HRID 2287056ノート

反応式

HRID 2287056 の反応式
[CH3:1][C:2]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11](=[O:20])[N:12]([CH2:14][CH:15](OC)[O:16]C)[CH3:13])[CH:6]=1)([CH3:4])[CH3:3].Cl>O>[CH3:1][C:2]([C:5]1[O:9][N:8]=[C:7]([N:10]2[CH:15]([OH:16])[CH2:14][N:12]([CH3:13])[C:11]2=[O:20])[CH:6]=1)([CH3:4])[CH3:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 12918839HCID 12918839、化合物

生成物 1

HCID 1569093-[5-tert-Butyl-3-isoxazolyl]-4-hydroxy-1-methyl-2-imidazolidinone収率 87.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A round bottom flask was charged with 2.6 grams of the 3-[5-(1,1-dimethylethyl)-3-isoxazoly]-1-methyl-(2,2-dimethoxyethyl)urea (prepared above), 150 milliliters of water and 1.5 milliliters of concentrated hydrochloric acid (HCl). The resulting mixture was heated until one phase formed, and crystals coated out on the sides of the flask and cooled; and the scrapings of the crystals and the solution were filtered. The crystalline precipitate was washed twice with separate portions of H2O, and then air dried to yield 1.9 grams of white crystals of 3-[5-(1,1-dimethylethyl-3-isoxazolyl]-1-methyl-4-hydroxy-2-imidazolidinone. M.P. 173°-177° C., IR spectra (mull.) bands at 3400, 3140, 1700, and 1590 cm-1.

後処理

  1. temperatureThe resulting mixture was heated until one phase
  2. customformed
  3. temperaturecooled
  4. filtrationand the scrapings of the crystals and the solution were filtered
  5. washThe crystalline precipitate was washed twice with separate portions of H2O
  6. customair dried

出典と根拠

ORDレコード
ord-c362994990f241ed87af13b52630c8f8
出典データセット
uspto-grants-1981_05
特許番号
US04268679

反応ノート

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