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Benzoic acid, 4-(aminomethyl)-, hydrochloride (1:1) → Benzylacetylene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoic acid, 4-(aminomethyl)-, hydrochloride (1:1) | HCID 105553 | — |
| 反応物 | 4-(Aminomethyl)benzonitrile hydrochloride | HCID 9942250 | — |
| 反応物 | 1-(prop-2-yn-1-yl)-1H-1,2,3-triazole | HCID 12709580 | — |
| 生成物 | Benzylacetylene | HCID 575753 | — |
反応手順
Replacing 4-cyanobenzylamine hydrochloride in Example 4, Step (1), with 4-carboxy-benzylamine hydrochloride, and replacing the 1-propyn-3-yl-1H-[1,2,3]triazole in Example 4, Step (2), with 3-phenyl-propyne yielded 4-[[3-3-phenethylethynyl-benzoylamino]-methyl}-benzoic acid; 1H-NMR (DMSO-d6) δ 9.2 (m, 1H), 8.0 (s, 1H), 7.8 (m, 4H), 7.6 (d, 1H) 7.2-7.4 (m, 7H), 4.5 (d, 2H), 3.9 (s, 2H) ppm. Mp 209° C.-211° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849648B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-e7347b90b4d94e468a7358d3e30b61e9 |
| 出典メモ | uspto-grants-2005_02 |